DNA methylation subtype classification can predict outcomes of urothelial carcinoma

Urothelial carcinoma (UC) is one of the most common malignancies genitourinary cancers, including upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). UTUC is more malignant, with 60% of patients having muscle invasion at diagnosis, compared with only 15–25% of UCB. Increasing evidence suggests that DNA methylation is closely related to tumor […]

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ACP offers guidance on the ethical use of genetic testing and precision medicine

A new position paper from the American College of Physicians (ACP) offers guidance regarding ethical decision-making for the integration of precision medicine and genetic testing into internal medicine. ACP’s advice is published in Annals of Internal Medicine. The paper was developed by ACP’s Ethics, Professionalism and Human Rights Committee in response to the issue of […]

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